Predictive Nomogram for Salvage Radiotherapy After Radical Prostatectomy

Selezionata da Pietro Cazzola, MD
  • Data from 2460 patients were used to describe outcomes in patients with node-negative prostate cancer treated with salvage radiotherapy (SRT) with or without androgen-deprivation therapy (ADT) after radical prostatectomy (RP) due to a detectable post-RP prostate-specific antigen (PSA). The median pre-SRT PSA was 0.5 ng/ml. The 5-year freedom from biochemical failure (FFBF) rate was significantly associated with pre-SRT PSA level. Other factors associated with FFBF were Gleason score, extraprostatic extension, seminal vesicle invasion, surgical margins, ADT use, and SRT dose. In addition, pre-SRT PSA, Gleason score, seminal vesicle invasion, surgical margins, and ADT use were associated with the risk for distant metastases.
     
  • Early SRT given to patients with low PSA levels is associated with improved outcomes.