Meta-Analysis of Tobacco Use and Prostate Cancer Mortality

F Islami, DM Moreira, P Boffetta, SJ Freedland

Cancro prostata fumoABSTRACT

CONTEXT
An association between tobacco smoking and prostate cancer (PCa) incidence and mortality was suggested in an earlier meta-analysis of 24 prospective studies in which dose-response associations and risks per unit of tobacco use were not examined.

OBJECTIVE
We investigated the association between several measures of tobacco use and PCa mortality (primary outcome) and incidence (secondary outcome) including dose-response association.

EVIDENCE ACQUISITION
Relevant articles from prospective studies were identified by searching the PubMed and Web of Science databases (through January 21, 2014) and reference lists of relevant articles. Combined relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random effects methods. We also calculated population attributable risk (PAR) for smoking and PCa mortality.

EVIDENCE SYNTHESIS
We included 51 articles in this meta-analysis (11823 PCa deaths, 50349 incident cases, and 4082606 cohort participants). Current cigarette smoking was associated with an increased risk of PCa death (RR: 1.24; 95% CI, 1.18-1.31), with little evidence for heterogeneity and publication bias. The number of cigarettes smoked per day had a dose-response association with PCa mortality (p=0.02; RR for 20 cigarettes per day: 1.20). The PAR for cigarette smoking and PCa deaths in the United States and Europe were 6.7% and 9.5%, respectively, corresponding to >10000 deaths/year in these two regions. Current cigarette smoking was inversely associated with incident PCa (RR: 0.90; 95% CI, 0.85-0.96), with high heterogeneity in the results. However, in studies completed in 1995 or earlier (considered as completed before the prostate-specific antigen screening era), ever smoking showed a positive association with incident PCa (RR: 1.06; 95% CI, 1.00-1.12) with little heterogeneity.

CONCLUSIONS
Combined evidence from observational studies shows a modest but statistically significant association between cigarette smoking and fatal PCa. Smoking appears to be a modifiable risk factor for PCa death.

F Islami, DM Moreira, P Boffetta, SJ Freedland
A Systematic Review and Meta-Analysis of Tobacco Use and Prostate Cancer Mortality and Incidence in Prospective Cohort Studies
Eur Urol 2014 Dec 01; 66(1)1054-1064