Recurrence of high-risk bladder cancer: A population-based analysis.

Chamie K, Litwin MS, Bassett JC, Daskivich TJ, Lai J, Hanley JM, Konety BR, Saigal CS; the Urologic Diseases in America Project.


Cancer. 2013 Jun 4. doi: 10.1002/cncr.28147. [Epub ahead of print]

Recurrence of high-risk bladder cancer: A population-based analysis.


Department of Urology, Health Services Research Group, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, California; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California.



Patients with bladder cancer are apt to develop multiple recurrences that require intervention. The recurrence, progression, andbladder cancer-related mortality rates were examined in a cohort of individuals with high-grade non-muscle-invasive bladder cancer.


Using linked Surveillance, Epidemiology, and End Results (SEER)-Medicare data, subjects were identified who had a diagnosis of high-grade, non-muscle-invasive disease in 1992 to 2002 and who were followed until 2007. Multivariate competing-risks regression analyses were then used to examine recurrence, progression, and bladder cancer-related mortality rates.


Of 7410 subjects, 2897 (39.1%) experienced a recurrence without progression, 2449 (33.0%) experienced disease progression, of whom 981 succumbed to bladder cancer. Using competing-risks regression analysis, the 10-year recurrence, progression, and bladder cancer-related mortality rates were found to be 74.3%, 33.3%, and 12.3%, respectively. Stage T1 was the only variable associated with a higher rate of recurrence. Women, black race, undifferentiated grade, and stage Tis and T1 were associated with a higher risk of progression and mortality. Advanced age (≥ 70) was associated with a higher risk of bladder cancer-related mortality.


Nearly three-fourths of patients diagnosed with high-risk bladder cancer will recur, progress, or die within 10 years of their diagnosis. Even though most patients do not die of bladder cancer, the vast majority endures the morbidity of recurrence and progression of theircancer. Increasing efforts should be made to offer patients intravesical therapy with the goal of minimizing the incidence of recurrences. Furthermore, the high recurrence rate seen during the first 2 years of diagnosis warrants an intense surveillance schedule. Cancer 2013. © 2013 American Cancer Society.

© 2013 American Cancer Society.