Patterns of Failure and Predictors of Outcome in Cutaneous Malignant Melanoma of the Scalp

BE Terakedis, CJ Anker, SA Leachman, RH Andtbacka, GM Bowen, WT Sause, KF Grossmann, TL Bowles, RD Noyes, YJ Hitchcock, KM Boucher, DC Shrieve

MelanomaABSTRACT

BACKGROUND
Patients with melanoma of the scalp may have higher failure rates than melanoma of other body sites.

OBJECTIVE
We sought to characterize survival and patterns of failure for patients with scalp melanoma.

METHODS
Between 1998 and 2010, 250 nonmetastatic patients underwent wide local excision of a primary scalp melanoma. Kaplan-Meier analyses were performed to evaluate overall survival, scalp control, regional neck control, distant metastases-free survival, and disease-free survival.

RESULTS
Five-year overall survival was 86%, 57%, and 45% for stages I, II, and III, respectively, and 5-year scalp control rates were 92%, 75%, and 63%, respectively. Five-year distant metastases-free survival for these stages were 92%, 65%, and 45%, respectively. Of the 74 patients who recurred, the site of first recurrence included distant disease in 47%, although 31% recurred in the scalp alone.

LIMITATIONS
This is a retrospective review.

CONCLUSION
Distant metastases-free survival and overall survival for stage II and III patients with scalp melanoma are poor, and stage III patients experience relatively high rates of scalp failure suggesting that these patients may benefit from additional adjuvant systemic and local therapy. Further research is needed to characterize the environmental, microenvironmental, and genetic causes of the increased aggressiveness of scalp melanoma and to identify more effective treatment and surveillance methods.

BE Terakedis, CJ Anker, SA Leachman, RH Andtbacka, GM Bowen, WT Sause, KF Grossmann, TL Bowles, RD Noyes, YJ Hitchcock, KM Boucher, DC Shrieve. Patterns of Failure and Predictors of Outcome in Cutaneous Malignant Melanoma of the Scalp.
J Am Acad Dermatol 2013 Dec 24;[EPub Ahead of Print]