A Retrospective Analysis of the Duration of Oral Antibiotic Therapy for the Treatment of Acne Among Adolescents

YH Lee, G Liu, DM Thiboutot, DL Leslie, JS Kirby

acneABSTRACT

BACKGROUND
Duration of oral antibiotic therapy in acne has not been widely studied. Recent guidelines suggest it should be limited to 3 to 6 months.

OBJECTIVE
We sought to compare the duration of oral antibiotic use with recent guidelines and determine the potential cost-savings related to shortened durations.

METHODS
This is a retrospective cohort study from the MarketScan Commercial Claims and Encounters database. Claims data were used to determine duration and costs of antibiotic therapy.

RESULTS
The mean course duration was 129 days. The majority (93%) of courses were less than 9 months. Among the 31,634 courses, 18,280 (57.8%) did not include concomitant topical retinoid therapy. The mean (95% confidence interval) duration with and without topical retinoid use was 133 (131.5-134.7) days and 127 (125.4-127.9) days, respectively. The mean excess direct cost of antibiotic treatment for longer than 6 months was $580.99/person.

LIMITATIONS
Claims cannot be attributed to a specific diagnosis or provider. The database does not provide information on acne severity.

CONCLUSIONS
Duration of antibiotic use is decreasing when compared with previous data. However, 5547 (17.53%) courses exceeded 6 months, highlighting an opportunity for reduced antibiotic use. If courses greater than 6 months were shortened to 6 months, savings would be $580.99/person.

YH Lee, G Liu, DM Thiboutot, DL Leslie, JS Kirby
A Retrospective Analysis of the Duration of Oral Antibiotic Therapy for the Treatment of Acne Among Adolescents: Investigating Practice Gaps and Potential Cost-Savings
J Am Acad Dermatol 2014 Apr 13;[EPub Ahead of Print]